Thirty people people died and 15 were injured when three microbuses crashed near Aswan on Monday morning, Al-Ahram Arabic news website reported.
The accident took place near the entrance of Edfo city north Aswan.
The injured were taken to Edfo general hospital, said health ministry official Mohamed Al-Weshahy.
Al-Weshahy added that an autopsy will be carried out on the casualties.
Meanwhile, the Governor of Aswan, Mostafa Yousry, told state news agency MENA that the victims were mostly fishermen returning to Fayoum, south of Cairo, from a short holiday.
Yousry added that one of the microbuses, travelling on the Aswan-Edfo road, crashed with another one coming from Luxor triggering the tragedy.
President Abdel Fattah El-Sisi ordered an immediate investigation into the crash, the cause of which is still unknown.
In August, nineteen people were killed and 17 injured when two minibuses plunged into a canal near Luxor.
Earlier in the same month, at least 44 people died and dozens were injured when two buses collided in South Sinai.
A recent government report said that 100,000 car accidents took place in Egypt from 2008 to 2012, with 33,000 killed and another 150,000 injured.