Twenty-three people were killed and 97 injured at protests around the country on the fourth anniversary of the 2011 revolution, the health ministry announced on Monday.
At least three policemen were among the dead, while most civilians were killed in Cairo’s Matariya district.
Out of the 97 people injured, 19 were members of the security forces.
Several protests took place on Monday to mark the fourth anniversary of the 2011 revolution, just a day after a female protester was killed at a march in downtown Cairo.
Clashes erupted between rival protesters or as police attempted to disperse the demonstrations.
Matariya witnessed the most intense events of the day as it is a hotbed for clashes between pro-Mohamed Morsi protesters and police, with weekly confrontations typical and deaths regularly reported.
Clashes also erupted in downtown Cairo between protesters and a number of supporters of President Abdel-Fattah El-Sisi during a protest at the Journalists Syndicate.
The protest was organised to demand retribution for those injured in the 2011 revolution. Demonstrators had chanted for retribution, as well as chanting against military rule and El-Sisi.
Security forces also dispersed a protest of about 100 supporters of El-Sisi in downtown Cairo's Abdel-Moneim Riyad Square, Aswat Masriya reported.