A civilian was killed and two others, including a firefighter, were injured as a blaze erupted on Monday in a three-storey building on El-Fagala Street off Ramsis Square, Health Ministry Spokesman Hossam Abdel-Ghafar told Ahram Online.
At least 17 fire trucks were dispatched to downtown Cairo as firefighters rescued two families from the second and third floor.
Part of the rear facade of the building collapsed and nearby buildings were evacuated.
Smoke could be seen rising from a distance.
The building is home to five bookshops located on the ground floor.
El-Fagala Street is well known as a commercial centre for bookshops as well as printing factories.