Ten people were killed and 20 others wounded Monday morning in a major traffic accident involving eight vehicles south of Cairo, Ahram Arabic news website reported.
The collision occurred near the Beni Suef governorate, 120 km (75 miles) south of Cairo.
Two trucks collided with five cars and a microbus on a highway near eastern Beni Suef.
Initial investigations showed the crash was the result of speeding and heavy fog.
Thousands die and tens of thousands are injured every year in near-daily road accidents in Egypt due to poor road safety and loosely enforced traffic regulations.
In its latest report in April, the country's census authority said that over 14,400 road accidents occurred in Egypt in 2014, killing more than 6,200 people and injuring over 25,000 others.
On Sunday, one person was killed and six others injured in a traffic accident on a motorway in the southern temple city of Luxor.