At least 15 people were killed on Tuesday morning in a road incident on the Eastern Desert Highway in Beni Suef governorate, Al-Ahram Arabic website reported.
The incident occurred when a truck ran into the rear of a microbus, Al-Ahram said.
The bodies of the victims were transferred to Beni Suef General Hospital and Nasser Central Hospital in the Upper Egyptian governorate.
Deadly road crashes take place on a near-daily basis in Egypt, which is notorious for poor road safety, badly maintained infrastructure, and loosely enforced traffic regulations.
In 2015, the country saw 25,500 road fatalities, while the total number of car accidents numbered 14,500, according to a study published by the official statistics body CAPMAS in August 2016.