Five people were killed and 12 others injured when a bus and a microbus collided on the Abu-Simbel-Aswan Highway on Monday morning, approximately 850km south of Cairo.
The dead include four Egyptians and a Sudanese national.
The injured were transferred to nearby hospitals.
Deadly road accidents take place on a near daily basis in Egypt, largely due to poor road safety, badly maintained infrastructure, and loosely enforced traffic regulations.
However, Egypt has allocated millions of pounds on developing and expanding road networks in recent years.
The country's official statistics agency said in April that more than 11,000 road accidents took place in Egypt in 2017, down from around 15,000 accidents the previous year.