Thirteen members of the Constitution Party's branch in Aswan, Upper Egypt, submitted their resignations on Saturday citing "lack of communication" with the Cairo headquarters as the reason.
The party's secretary-general in Aswan Mahmoud Moussa and 12 other leading members addressed their resignations on Saturday to Mohamed El-Baradei, the party's current leader and prominent opposition figure.
According to state news agency MENA, the 13 members said that their resignation was in protest at the party's "internal policy" and lack of democracy.
"We did not find the political role [that the party needed to carry out], only personalities pursuing personal interest," their resignation reads, according to MENA.
The Constitution Party has been facing internal conflicts recently.
On Monday, a group of the party's young members stormed its headquarters in Cairo and occupied it. They demanded dismissing the party's leadership and creating a new steering committee.