Syrian State television reported that President Bashar al-Assad sacked the governor of Hama, a day after half a million protesters flooded the central city demanding the ouster of their embattled leader.
Most of Friday's victims were killed in the Idlib province, where all week troops backed by tanks and armoured personnel carriers have swept through villages to crush dissent against Assad's autocratic regime.
"Sixteen people were killed" in Idlib on Friday, Ammar Qorabi, the head of the National Organisation for Human Rights, told AFP in Nicosia on Saturday. Three of them were women who died when the army shelled a chicken hatchery in the village of Al-Bara, Qorabi said.
Another 10 people were killed when security forces opened fire to disperse protests in several cities, including eight in the central protest hub of Homs and two in the Damascus neighbourhood of Qadam.
One person was reported killed in Syria's second-largest city Aleppo and another in the Mediterranean coastal city of Latakia.
A previous death toll provided by other activists late Friday gave a figure of 11 civilians dead, including a 50-year-old mother and her 20-year-old daughter killed in Al-Bara.
Waves of protesters flooded the streets nationwide on Friday to demand the overthrow of the regime, with varying reports putting the turnout in the central city of Hama alone at more than half a million.
The head of the Syrian Observatory for Human Rights, Rami Abdel Rahman, spoke of 500,000 protesters and said this was "the biggest demonstration since the Syrian Revolution broke out" on March 15.
Another activist said that "more than 400,000 marched."
A third said more than 200,000 people gathered in the city's Assi Square, stretching for more than one kilometre (nearly a mile), and that there was no sign of security forces.
Hama has a bloody past. In 1982, an estimated 20,000 people were killed when the army put down an Islamist revolt.
Assad sacked Hama's governor on Saturday. "The Syrian president signed a decree today (Saturday) relieving Doctor Ahmad Khaled Abdel Aziz of his post as governor of Hama," state television said in an urgent news flash.
On Friday, an activist said that "more than 100,000 people" had protested in several districts of Homs as tanks were deployed.
Friday's protests followed a call from the Facebook group, The Syrian Revolution 2011, which called on people to rally, branding July 1 "the Friday of departure" and saying in a message to Assad: "We don't love you... Go away, you and your party."
More than 1,360 civilians have been killed in the government's crackdown against pro-democracy protests since mid-March, according to human rights groups.