US-led airstrikes have killed "several hundred" jihadists fighters in and around Kobane, but the Islamic State group could still seize the besieged strategic Syrian town, the Pentagon said Wednesday.

"We believe that we have killed several hundred ISIL fighters in and around Kobane," Pentagon spokesman John Kirby told reporters, adding that the majority of the city's population has fled as jihadists continued to pour into the region in an attempt to take the town.