An air strike targeted the office of the presidency in Yemen's rebel-held capital Sanaa on Monday, residents said, with rebel Al-Masirah television blaming the Saudi-led coalition for the raid.
There was no immediate information on casualties, but witnesses said the office, used by the Huthi rebel administration, is normally bustling with employees.
Residents said they heard two explosions hit the building, which is located near a hotel, a bank and shops, and not far from the central bank.
The Huthis' Al-Masirah television accused the Saudi-led coalition, which has been fighting the rebels since 2015 to shore up the internationally recognised government, of responsibility for the strike.
The coalition could not immediately be reached for comment.
The strike came hours after Saudi Arabia's air defenses intercepted two ballistic missiles launched by the Huthis that targeted the south of the kingdom, said coalition spokesman Colonel Turki al-Malki.
He said the rockets were launched from northern Yemen toward "populated areas" of Saudi Arabia, but were intercepted overnight without any casualties or damage.
"This hostile act... proves the continued involvement of the Iranian regime in supporting the Huthi militia with qualitative capabilities," Malki added.
Since November of last year, the Iran-backed insurgents have intensified missile attacks into neighbouring Saudi Arabia.
The Saudi-led coalition launched a military intervention in Yemen in 2015 with the goal of rolling back the Huthis and restoring the internationally-recognised government to power.
The conflict has left nearly 10,000 people killed, tens of thousands wounded, and millions on the brink of famine in what the United Nations has called the world's worst humanitarian crisis.