Syrian troops besieged Daraya on Tuesday and rained shells on the town near Damascus, killing a woman and a child, in a fresh attempt to storm it, activists and a watchdog said.
The Syrian Observatory for Human Rights also reported that at least 29 people have died over the past 24 hours in clashes between Kurdish militiamen and rebels in the northern Syria town of Ras al-Ain, near the Turkey border.
"We have been under constant rocket and artillery fire," Abu Kinan, an activist from Daraya southwest of Damascus, told AFP via Skype, adding that troops had rigged the area with checkpoints and arrested scores of people.
"There is no life in all of Daraya," he said, estimating that 90 percent of the residents had fled the town in panic.
"The clashes are some of the heaviest we have seen. The Republican Guard came to reinforce the regime army," he said.
Rebel Free Syrian Army fighters are locked in fierce battles with regime troops on the edge of the town, he added.
At least two civilians, a woman and a child, were killed by army bombardments on Daraya, the Observatory said, in the latest of several attempts to storm the town over the past few days, the watchdog said.
Considered a heartland of non-violent activism, Daraya was the site of the worst massacre in Syria's 20-month conflict, with more than 500 people killed there in late August, according to monitors.
The Observatory also reported shelling attacks across the eastern outskirts of Damascus while state media said two mortars hit the ministry of information in the west of the capital, causing no casualties.
In the northern province of Aleppo, rebels attacked the Sheikh Suleiman air defence battalion, less than two days after a military source said the insurgents took control of the sprawling Base 46 in the same province.
The Observatory said casualties from clashes in Ras al-Ain included four Kurdish fighters, a local Kurdish official, and 24 members of the Islamist Al-Nusra Front and Gharba al-Sham rebel battalions.
The Kurdish fighters are members of the People's Defence Units, the armed wing of the Democratic Union Party (PYD), which is linked to Turkey's rebel Kurdistan Workers' Party (PKK), said the British-based watchdog.
A Ras al-Ain activist, who gave his name only as Hevidar, said that tension has been high between rebels an the PYD since the insurgents took the town last week.
The clashes on Monday erupted after a Kurdish demonstration, which demanded that all rebels not from the town leave, was met with refusal.
The Observatory, which relies on a network of activists, lawyers and medics in civilian and military hospitals, gave an initial toll of at least 30 people killed across Syria on Tuesday.
The dead include nine soldiers who died in the central town of Mahin, east of Homs, when a truck rigged with explosives was detonated near a weapons depot. At least 20 soldiers were wounded in the blast.