Germany warned Friday that it would not accept any new US sanctions against Russia that targeted European companies at the same time.
Foreign Minister Sigmar Gabriel underlined the importance of applying economic pressure on Russia over its involvement in the Ukrainian conflict.
But he stressed in a statement that "we will under no circumstances accept an extraterritorial application of these US sanctions against European companies."
"Sanction policy is neither a suitable nor an adequate instrument to advance the interests of national exports and the domestic energy sector."
European nations have lashed out at Washington over the impact of the new sanctions, arguing that they could hurt European companies involved in the construction of a new pipeline that would pump Russian gas under the Baltic Sea directly to Germany.
They fear that the US could use the sanctions to squeeze Russian gas supplies out of Europe in favour of US energy exports.
The EU has also warned of swift retaliation if the US pushed ahead with the sanctions without taking heed of its concerns.
To date, anti-Russia sanctions have been coordinated on both sides of the Atlantic in a common Western front reminiscent of the Cold War.
But on Thursday, the US Senate passed the sanctions package despite European concerns, sending it to President Donald Trump, who must decide whether to accept the tough stance or veto the measure.