Ahly midfielder Hossam Ashour and defender Mohamed Naguib will miss the club’s first game in the African Champions League round of 32 against Recreativo de Libolo scheduled for Saturday in Angola.
Naguib, 33, who missed the last two league games against Petrojet and Maqassa, is still suffering back muscle pains while Ashour, 29, sustained a thigh injury during the team's Maqassa 2-1 victory.
First goalkeeper Sherif Ekramy has recovered from his hamstring injury and will be fit for the trip.
Ahly remain on top of the league table with 47 points from 21 games, six ahead of the second-placed Zamalek.
The record holders of eight African Champions League trophies will fly to Angola on Wednesday morning for the African clash, a week before the second leg scheduled for 19 March in Cairo.
Ahly are representing Egypt in the African Champions League this season alongside league winners Zamalek after placing second in the Egyptian Premier League last season.
Their archrivals Zamalek will be facing Union Sportive de Douala of Cameroon in the same round on the same dates.
The two Cairo giants have just hired new European coaches - Ahly signed former Tottenham manager and Dutchman Martin Jol while Zamalek landed Scotland's Alex McLeish.
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