Friday 16 March

Supersport United FC 2-1 Atlético Petróleos de Luanda (0-0)
Supersport United advance with a 2-1 aggregate win 

El Ahly Shandy 2-1 CS La Mancha (0-3)
CS La Mancha advance with a 4-2 aggregate win 

Saturday 17 March 

Nkana FC 1-0 CR Belouizdad (0-3)
CR Belouizdad advance with a 3-1 aggregate win.

APR FC 2-1 Djoliba AC de Bamako (0-1)
Djoliba advance on the away goal rule after a 2-2 draw on aggregate.

Club Africain 0-1 Renaissance Sportive de Berkane (1-3)
RS de Berkane advance with a 4-1 aggregate win.

FC Nouadhibou 2-4 Raja Club Athletic (1-1)
Raja advance with a 5-3 aggregate win.

Al Hilal Elobied 6-0 Olympic Star FC (0-0)
Al-Hilal advance on a 6-0 aggregate win.

Masry 0-0 Simba Sports Club (2-2)
Masry advance on the away goal rule after a 2-2 draw on aggregate.

Sunday 18 March

Fosa Juniors 1-0 AS Port Louis 2000 (2-0)
Fosa Juniors  advance on a 3-0 aggregate win

Union Sportive Ben Guerdane 3-1 CARA Brazzaville (0-3)
CARA Brazzaville advance on a 4-3 aggregate win

Cape Town City 1-2 Club Desportivo Costa Do Sol (1-0)
Club Desportivo Costa Do Sol  advance on the away goal rule after a 2-2 on  aggregate 

Enyimba FC 3-2 Energie (2-0)
Enyimba advance with a 5-2 aggregate win

Akwa United FC, Uyo vs. Al Ittihad (0-1)
Akwa United advance with 3-2 on penalties after a 1-1 draw on aggregate 

Deportivo Niefang 1-0 DC Motema Pembe (1-1)
Deportivo Niefanga advance with a 2-1 aggregate win

Zamalek 2-1 Wolaitta Dicha SC (1-2)
Wolaitta Dicha SC advance with 4-3 on penalties after a 3-3 draw on aggregate 

U.S.M Alger 1-0 AS Maniema Union (2-2)
U.S.M Alger  advance with a 2-1 aggregate win

* First leg results between brackets

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