Zamalek bounced-back on Thursday from their Arab defeat last week they defeated Masry in a postponed league game at Alexandria's Borg El-Arab stadium.
On Friday, the 12-time league champions were eliminated from the Zayed Cup round of 16 after losing to Ittihad of Alexandria 3-4 on Penalties.
Mahmoud 'Kahraba' Abdel-Moneam opened the scoring in the 12th minute, while Youssef 'Obama' doubled the score, seven minutes before the break.
Both players netted their seventh league goal this season, one goal short of their teammate Mahmoud Alaa who is leading the League top scorers list with eight goals.
Zamalek's Thursday's win is the seventh in a row in the Egyptian league this season and puts the Cairo giants on top of the table with 35 points, nine points ahead of second-place Pyramids.
The White Knights opened the scoring thanks to a nice curling shot from winger Mahmoud Kahraba from outside the area.
After the goal, Zamalek maintained their domination but they failed to double the seal against a Masry side that appeared incapable of leveling the score.
Seven minutes before the break, Youssef Ibrahim received a nice pass from Tunisian fullback Hamdi Nagguez to score easily from close-range.
Masry coach Moustafa Youness made a double substitution, introducing attacking midfielders Ahmed Shoukri and Eslam Atteya in order to strengthen their frontline.
The duo gave Masry the chance to threaten Zamalek on many occasions, but international Keeper Mahmoud 'Gennesh' Abdel-Rehim secured the win for his side.
Winger Moustafa Fathi, who made his first start this season, had the chance to add the third but his effort went wide.
The second halftime saw forced substitutions of three Zamalek players, Abdallah Gomaa, Ferjani Sassi and Moustafa Fathi, all left the pitch with different injuries.
Zamalek's opens their Confederation Cup campaign next week away against Chad's Cotton.