Egyptian side Zamalek were drawn to face Morocco's Hassania Agadir in the quarter finals of the African Confederation Cup on Wednesday.
Zamalek finished on top of Group D with nine points while Agadir were runners up in Group A with eight points.
The Cairo giants, who won the elite Champions League five times, have never won Africa's secondary club competition.
In other last-eight clashes, Kenya's Gor Mahia, who finished second behind Zamalek, will face another Moroccan outfit in RS Berkane while Tunisia's Etoile Sahel will play Al-Hilal of Sudan.
Zambia's Nkana face a tough duel against Tunisian side Sfaxien, winners of four Confederation Cup titles.
The first legs will be held on 7 April, with the return matches taking place a week later.