Zamalek will be looking to go to the top of the Egyptian Premier League when they face joint leaders and stiff rivals Pyramids FC on Tuesday.
The Whites regained their place at the top of the league after beating Ismaily 2-0 in their last league match on Thursday.
They currently lead the table with 60 points from 26 matches; the same points as Pyramids FC, who played two matches more, but with a better goal difference for Zamalek.
Besides the anticipated clash against third-placed Ahly, Pyramids FC is the other main obstacle in Zamalek's road to win their first league title since the 2014/2015 season.
On the other side, rising football powerhouse Pyramids are likely to give Zamalek a stiff test as they want to continue their recent fine run in the Egyptian league under Argentinean coach Ramon Diaz.
On Thursday, the big spenders and title contender Pyramids secured their fifth successive league win; beating champions Ahly 1-0 to make the title race more exciting.
The Pyramids-Zamalek confrontation in the league's first round ended with a 3-3 draw.
Zamalek's Swiss boss Christian Gross got a blow as some key players will be missing on Tuesday due to injury, including Moroccan striker Khalid Boutaib, Tunisian midfield star Ferjani Sassi, Moroccan winger Hamid Ahddad and right-winger Hazem Emam.
Winger Mahmoud Kahraba was cleared fit to boost Zamalek against Pyramids, while defence duo Tunisian international Hamdi Nagguez and Mahmoud Hamdy will also be available after missing last game due to suspension.
Pyramids' attacking line will be boosted by the return of Peruvian midfielder Cristian Benavente from injury and Syrian striker Omar Kharbin from suspension.
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