Zamalek will be looking to join Cairo rivals Ahly in the Egyptian Premier League's decisive round when they meet Arab Contractors on Monday.
A win for the White Knights will be enough to lift them to the final mini-league as they bid to end a nine-year league drought.
Bitter foes Ahly, who play in the other group, have already reached the final phase after defeating Haras El-Hodoud 2-1 on Sunday.
Zamalek are also looking to make up for a surprising 2-1 defeat by Petrojet last week which ended their 10-match winless streak.
"A defeat is not the end of the world. It's a chance to correct our errors, especially that we steadily marching on in the Egyptian league and African Champions League," Zamalek goalkeeper and skipper Abdel-Wahed El-Sayed said on the club's official website.
"The gap over our opponents shows that we are not under pressure at all. The players are capable of quickly returning to winning ways,"
Zamalek, who have made their best-ever league start, are on top of Group A of the league's new format with 30 points from 11 games, six clear of second-placed Ismaily.
If they beat Contractors they will gain an unassailable lead over their challengers, apart from Ismaily.
The top two in Groups A and B will qualify for the final round, where a mini-league with only home fixtures will be held to determine the champion.
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