Sofapaka (KEN) 1-0 St Eloi Lupopo (COD)
St Eloi Lupopo (COD) 2-1 Sofapaka (KEN)
Scorers: Kapesa Bangala 22, Oswald 40 / Humphrey Mieno 89
Sofapaka qualify on the away goal rule after a 2-2 tie result

Adema (MAD) 1-0 Difaa al-Jadida (MAR)
Scorers: Tyala Kénédi 3
Difaa al-Jadida (MAR) 3-0 Adema (MAD)
Scorers: Hadraf 15, 78, Chakir 90+3-pen
Difaa al-Jadida qualify after winning 3-1 on aggregate

Al-Khartoum (SUD) 2-0 Moghreb Fes (MAR)
Scorers: Salah Al-Amir (Pen) 9, Ammari 16
Moghreb Fes (MAR) 5-1 Al-Khartoum (SUD)
Scorers: Chihani 13, Sektioui 40, 51, 57, Abourazzouk 81 / Mohamed Taib 69
Moghreb Fes qualify after winning 5-3 on aggregate

Primeiro Agosto (ANG) 1-0 FUS Rabat (MAR)
Scorers: Amaro (pen) 34
FUS Rabat (MAR, holders) 1-1  Primeiro Agosto (ANG)
Scorers: Rokki 82 / Rodriguez 89
Primeiro Agosto qualify after winning 2-1 on aggregate

DC Motema Pembe (COD) 2-1 (4-3 pen) Harras Al-Hodoud
Scorers: Salakiaku 20,32 / Safy 46
Harras al-Hodoud (EGY) 2-1 DC Motema Pembe (COD)
Scorers: Mekky 17, Said 54 / Tresor Matondo 21
DC Motema Pembe qualify after winning 4-3 on penalties
 
JS Kabylie (ALG) 3-0 Missile FC (GAB) 
Scorers: Tedjar 11-pen, 35, Yahia 60 
Missile (GAB) 3-0 JS Kabylie (ALG)
Scorers: Geoffroy Ngame Essono 47-pen, Claude-Mve Mintsa 60, Max Dany-Karl 81
JS Kabylie qualify after winning 3-0 on penalties
  
USFA (BUR) 1-0 Sunshine Stars (NGR)
Scorers:
Sunshine Stars (NGR) 2-0 USFA (BUR)
Scorers: Emmanuel 67, 90
 

Kaduna Utd (NGR) v Etoile Sahel (TUN)
Etoile refused to travel to Nigeria because of lack of security

Note: Winners play-off against African Champions League third round losers