The Spanish rivals renew their explosive rivalry at the Santiago Bernabeu where Guardiola has yet to lose a match since taking charge in 2008.
Guardiola says the whole squad will travel to the Spanish capital without revealing whether Xavi Hernandez, Gerard Pique or Sergio Busquets would be available despite injury. Defender Carles Puyol was recovering from knee surgery.
International commitments have kept Barcelona’s complete squad from training together until this week.
Guardiola says there is no favorite and “anything can happen.”