"Why not? It's just another football team. I think I know the game and I know what I'm doing," he said, before admitting that he would consider such an offer were it to come along.
Loew has been Germany coach since 2006, leading them to the final of Euro 2008 and to third place at the 2010 World Cup.
His current deal is due to expire after Euro 2012.
"I firmly believe that things can develop favourably for you if you remain fully focused on what you are doing," said Klopp, 44, before revealing how his wish to become coach of Mainz at the end of his playing days came true.
"I really wanted to become a coach. A year-and-a-half later I was offered the job and I accepted it straight away," he said.
After spending seven years at Mainz, Klopp joined Dortmund in 2008, before leading them to the Bundesliga title last season.