Forlan injured his left leg in a World Cup qualifying match against Paraguay on Oct. 11, but Inter coach Claudio Ranieri has included Forlan among his 22-man squad for the trip to Genoa.
The 32-year-old Forlan joined Inter from Atletico Madrid in the offseason and scored a goal on his debut, a 4-3 loss to Palermo.
Inter is 11th in the standings with 17 points from 13 games.
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