The 26-year-old Russian -- presently number three in the world -- had had to withdraw from the US Open on the eve of the tournament because of the injury and owing to a previous hip problem has played just one match since a second round exit at Wimbledon in June.
"I am very disappointed that I will not be able to play in the WTA Championships this year," said Sharapova, whose turbulent season has also been marked by her splitting with Jimmy Connors after just three weeks as her coach.
"The fans in Istanbul have welcomed us each year with such intense passion and warmth, I will sincerely miss the energy and excitement they brought to the year-end tournament.
"I want to thank Istanbul for being a tremendous host and hope to play in Turkey sometime in the future."
While the crowd-pulling Russian won't be there the WTA also announced that three further players had qualified for the tournament which takes place from October 22-27.
The trio are Czech Republic's Petra Kvitova, winner of two titles this season, Italy's Sara Errani, who has won one of her four finals this campaign, and Serbia's Jelena Jankovic, who ended a three year title drought when she won in Bogota.
They join the already qualified Serena Williams, Victoria Azarenka, Agnieszka Radwanska and Chinese star Li Na.
The WTA Championships features the top eight singles players and the top four doubles pairings competing for a record $6 million in prize money and is being hosted in Istanbul for a third successive year.
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