Last Update 21:11
Friday, 20 September 2019

Personalized cancer treatment wins FDA approval

The treatment targets tumors with specific genetic mutations, irrespective of where in the body the disease started

Reuters , Sunday 18 Aug 2019
Reuters
Share/Bookmark
Views: 2289
Share/Bookmark
Views: 2289

The U.S. Food and Drug Administration approved Roche Holding AG’s personalized cancer treatment, which targets tumors with specific genetic mutations, irrespective of where in the body the disease started, the agency said .

The treatment, Rozlytrek, is a tyrosine kinase inhibitor that targets patients who must be identified via genetic profiling. It is approved to treat certain types of solid tumors, which show rare genetic anomalies called NTRK fusions.

Individually, the mutations are rare and it is difficult to run dedicated tests for each. They have been identified in a broad range of solid tumor types, including breast, colorectal, pancreatic and non-small cell lung cancers, the company said.

Since these NTRK fusions occur in a multitude of tumors, Roche sees potentially broad application for Rozlytrek, in conjunction with diagnostic tests from its Foundation Medicine unit.

Rozlytrek, already approved in Japan, is now available in the United States for adults and children 12 years of age and older, the company said.

The FDA  also approved it to treat adult patients with non-small cell lung cancer, whose tumors show a genetic mutation called ROS1 fusion.

Rival treatment Vitrakvi from German drugmaker Bayer has already won U.S. backing for solid tumors that test positive for NTRK genes.

Short link:

 

Email
 
Name
 
Comment's
Title
 
Comment
Ahram Online welcomes readers' comments on all issues covered by the site, along with any criticisms and/or corrections. Readers are asked to limit their feedback to a maximum of 1000 characters (roughly 200 words). All comments/criticisms will, however, be subject to the following code
  • We will not publish comments which contain rude or abusive language, libelous statements, slander and personal attacks against any person/s.
  • We will not publish comments which contain racist remarks or any kind of racial or religious incitement against any group of people, in Egypt or outside it.
  • We welcome criticism of our reports and articles but we will not publish personal attacks, slander or fabrications directed against our reporters and contributing writers.
  • We reserve the right to correct, when at all possible, obvious errors in spelling and grammar. However, due to time and staffing constraints such corrections will not be made across the board or on a regular basis.
Latest

© 2010 Ahram Online.