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Fewer kids dying from leukemia: study

Kids with one type of leukemia are living longer than they used to, most likely due to new drug combinations

Reuters, Sunday 18 Mar 2012
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In a study including more than 20,000 babies, kids and adolescents with the blood and bone marrow cancer, patients' chances of surviving at least five years after their diagnosis increased from 84 per cent in the early 1990s to over 90 per cent a decade later.

In people with acute lymphoblastic leukemia, or ALL -- the most common type of childhood cancer -- the bone marrow makes too many immature white blood cells instead of producing the cells necessary to fight infections.

Fifty years ago, the disease killed almost everyone it struck within a few years. But survival rates steadily rose over the next decades as doctors gained more tools to treat leukemia.

To see if that trend has been continuing, the researchers consulted patient information from Children's Oncology Group studies, which include more than half of kids diagnosed in the United States with leukemia, between 1990 and 2005.

Out of about 21,600 kids and adolescents up to age 22, 83.7 per cent who were diagnosed with leukemia between 1990 and 1994 were still alive five years later, and 80.1 per cent survived at least 10 years post-diagnosis.

Among those who were diagnosed between 2000 and 2005, 90.4 per cent survived at least five years, and 10-year survival rates seemed to be trending upward as well, the researchers reported in the Journal of Clinical Oncology.

Hunger and his colleagues found that both younger kids and adolescents were less likely to die of leukemia in recent years, as were white, black and Hispanic kids and those with higher-risk and lower-risk forms of cancer.

The one exception was infants, who when they do get leukemia, tend to have very aggressive disease. Only about half of infants survived five years after being diagnosed in both the early and later years of the study.

NEW TREATMENT REGIMENS

While the chemotherapy drugs considered standard for leukemia treatment haven't changed a lot in recent years, researchers said that advances in drug combinations and doses that better stave off disease relapses are likely behind improvements in survival.

The small drop-off in the number of kids who survive at least 10 years versus five years after a leukemia diagnosis is evidence of that.

"A child with ALL who is alive and in first remission five years after diagnosis has an outstanding chance of long-term cure,"said Dr. Stephen Hunger from the University of Colorado School of Medicine and Children's Hospital Colorado in Aurora, who worked on the study.

He said he doesn't think that the improved survival at five years is due to more cancers being caught early -- which would start the clock on survival ticking sooner. Hunger said he expects the lower rates of death to continue showing up years down the line.

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