OIC chief Ekmeleddin Ihsanoglu urged "the Syrian leadership to exercise utmost restraint through immediate cessation of the use of force to suppress people's demonstrations," said the world's largest pan-Islamic body.
It called on Damascus "to engage in dialogue with all parties in Syria in order to agree on acceptable reform measures and to expedite their implementation."
Ihsanoglu "expressed the readiness of the Organisation of Islamic Cooperation to play a role in this regard, as he believes that dialogue is the only secure option through which this devastating crisis could be contained."
Security forces backed by tanks have been trying to crush dissent city by city and town by town since pro-democracy protests erupted in mid-March.
The Syrian Observatory for Human Rights says 2,150 people have since been confirmed dead.
The UN Security Council is to hold a special meeting next Thursday to discuss human rights and the humanitarian emergency in Syria, diplomats at the United Nations said.
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