The Islamic State (IS) militant group denied on Friday it had suffered casualties from the US military's largest non-nuclear bomb which hit its mountain hideouts in Afghanistan, in a statement on its propaganda agency Amaq.

"Security source to Amaq agency denies any dead or wounded from yesterday's American strike in Nangarhar using a GBU-43/B," the group's self-styled news agency said on social media accounts.

The GBU-43/B Massive Ordnance Air Blast bomb -- dubbed the "Mother Of All Bombs" -- was unleashed in combat for the first time on Thursday, hitting IS positions in eastern Nangarhar province.