The luck of the draw is pitting champions Zamalek against Enppi in their opening game and heavyweights Ahly versus Ismaily.
The Premier League revealed that no structural changes have been made to the tournament ahead of this new season, with the league still comprising 18 teams that will each play two legs, resulting in 34 matches per team.
The Cairo derby will take place in an early stage of the league, as titleholders Zamalek will host Ahly in the third round.
The dates of the fixtures will be announced later on Tuesday when the draw fully concludes.
Ismaily vs Ahly
Zamalek vs Enppi
Pyramids FC vs Makassa
Future FC vs Pharco FC
Smouha vs Ittihad of Alexandria
Ghazl Al-Mahalla vs Masry
Arab Contractors vs Eastern Co.
Gouna vs Ceramica Cleopatra
NBE Club vs T. Al-Gaish
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