Masry played out a 0-0 draw away to Uganda s Revenue Authority in the first leg (Photo: the club s official Twitter account)
Both sides labored on the road in the first legs, failing to mount threats in two dull 0-0 draws.
Pyramids, who are making their third appearance in Africa's secondary club competition, host Azam in a 21:00 (19:00 GMT) kick-off at their Air Defence venue in Cairo.
"We are hoping to score an early goal that would make things easier for us," said Pyramids coach Ihab Galal.
The Emirati-owned club reached the final in 2020 but lost to Morocco's RS Berkane 1-0. They were the victims of another Moroccan outfit a year later, slumping to a shootout defeat by Raja in the semi-final following a 0-0 aggregate draw.
Masry, who are based in Port Said, meet Revenue Authority in the Mediterranean city of Alexandria at 19:00 (17:00 GMT).
Tunisian coach Moine Chaabani, a two-time African Champions League winner with Esperance, will be eyeing his first win at the helm after his debut ended in a bore stalemate.
Masry took part in the Confederation Cup for four straight years (2017-20), reaching the semi-final in 2018 and the quarters on their last participation in 2020.
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