Three days after United beat Liverpool 4-0 to open its overseas tour in Bangkok, the Victory took advantage of some apparent jet lag by the visitors to grab a 1-0 lead in the fifth minute when Chris Ikonomidis scored.
But United led at halftime after a deflected Scott McTominay strike and a close-range Anthony Martial goal.
The Dutch manager, hired by the English Premier League team in April, changed all 10 outfield players at halftime, just as he did against Liverpool. Marcus Rashford's finish from an Eric Bailly through ball provided the highlight of the second half that ended with an own goal from Tahith Chong's cross.
United next plays on Tuesday against Crystal Palace, also at Melbourne, before it faces Aston Villa next Friday in Perth, Western Australia.
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