Members of Israeli security forces and emergency services inspect the site of a reported attack on an Israeli bus, east of Tubas village in the north of the occupied West Bank, on Sept. 4, 2022. AFP
The attack in the Jordan Valley, near the city of Tubas, comes amid a spate of violence in the West Bank in recent days.
It also follows months of often deadly Israeli army raids in the West Bank, many targeting Palestinian in the Nablus and Jenin areas, both near Tubas.
Two suspects were arrested soon after Sunday's attack near the burnt-out remains of the vehicle they were thought to have used, and guns were found lying on the dirt road nearby.
The bus's windscreen was peppered with dozens of bullet holes and a side window was smashed.
The Israeli military said one soldier was seriously wounded and five others and a civilian suffered lighter injuries.
"We saw two gunshot victims outside of the bus who were being treated by IDF (Israeli military) medics and other people who were at the scene," said paramedic Matti Carmi, from the Magen David Adom emergency medical services.
Those shot in the northern West Bank incident were both conscious and were airlifted to Rambam hospital, in the city of Haifa.
Three others were hit with glass fragments and subsequently transferred by road to another hospital in northern Israel, MDA said.
A photograph published by a union representing bus drivers showed the vehicle's windscreen peppered with bullet holes.
Sunday's incident follows a shooting spree last month targeting an Israeli bus in occupied east Jerusalem.
Eight people, including several American citizens, were wounded in that pre-dawn attack near the Old City of Jerusalem.
Following an hours-long manhunt, police said a suspect had handed himself in.
Israel has controlled east Jerusalem and the West Bank since the 1967 Six-Day War, when it seized the territories from Jordan.