Any attempt to reclaim the territory would provide the grounds for Russia to use “any” weapon, including nuclear weapons, Medvedev said.

Russia annexed Crimea from Ukraine in 2014.

"Any attempt to split off a portion of the state would be a violation of the existence of the state itself," he warned.

"Ukraine will not join the European Union, and promises to reassure people in this regard are a lie," he added.

Medvedev has repeatedly warned that continuing to supply weapons to Kyiv could result in a global nuclear disaster.

His repeated statements have been interpreted as an effort to dissuade NATO and Kyiv's western allies from becoming more involved in the year-old conflict, in which Moscow has experienced setbacks on the battlefield.

"Contacts between Russia and the European Union remain active in a number of areas in which interaction is required, but there is rudeness towards Moscow from Brussels."

"Our adversaries do exactly that; they refuse to recognize that their goals will inevitably fail." Everyone suffered a setback. A breakdown. The end of the planet has arrived. "You will forget what your life was like for centuries until the rubble stops emitting radiation," he continued.

At the same time, Medvedev thinks that Ukraine's claims about retaking Crimea are mainly propaganda.

"All kinds of comments about retaking Crimea or whatever... This is, after all, propaganda, and it should be regarded as such. You always see it during wartime," he stated.