The Red Devils are leading the table with 56 points from 22 matches and hope they can open a seven-point gap at the top before heading to the Champions League final.
Ahly will be without first-choice goalkeeper Mohamed El-Shennawy and second-choice Ali Lotfi due to calf and thigh muscle injuries respectively.
Fourth-choice keeper Hamza Alaa has also been injured, which leaves coach Marcel Koller with Mostafa Shobeir as the only available option between the sticks and youth goalkeeper Mostafa Mokhlouf on the bench.
Forwards Hussein El-Shahat, Mahmoud "Kahraba" Abdel-Moneim and Mohamed Sherif and defender Yasser Ibrahim are doubtful for the game as they did not train with the rest of the squad on Thursday.
However, international defender Mohamed Abdel-Moneim will be available for selection after being rested from the previous game against Enppi.
El Gaish are battling for survival as they are 17th from the 18-team table with 26 points from 27 games and cannot afford any drop in points.