The leader of the Justice Party, Abdelmonem Emam, announced the news on Facebook, describing Isaac as "the saint of national work."

Isaac carved out a notable place in Egypt's political landscape, particularly as a founding member of the Civil Democratic Movement in 2014. This liberal political alliance comprised parties such as the Social Democratic Party and the Bread and Freedom Party.

He also served as general coordinator of the Kefaya (Enough) Movement, officially known as the Egyptian Movement for Change. Formed in 2004, the movement was as a vocal critic of former President Hosni Mubarak's regime and vehemently opposed the notion of dynastic succession within the presidency, particularly after the 2005 presidential elections.

George Isaac's unwavering commitment to social justice was evident during the transformative events of the January Revolution in 2011. His active participation in the protests, notably as a Christian safeguarding Muslim worshippers in Tahrir Square, demonstrated his dedication to national unity and protecting the rights of all citizens.

The official page of the Civil Democratic Movement mourned his passing, celebrating him as “a rare embodiment of the authentic Egyptian character” and a symbol for “toughness, benevolence and optimism.”

The National Council for Human Rights (NCHR), of which Isaac was a respected member until his passing, acknowledged his impact in inspiring Egyptians across different affiliations, a man who left behind a "great human legacy" and a “bright page in political history.”

Isaac’s funeral will be held on Sunday at the Coptic Orthodox Cathedral in Abbassiya.