Midfielder Ahmed Hamdi scored the winner in the 23rd minute with a well-placed shot from inside the penalty area.
Despite losing the first leg 2-1 in Morocco, Zamalek won the title on the away goal rule, following a 2-2 aggregate draw.
This victory marks Zamalek's second Confederation Cup title, with their previous win occurring in 2019 against the same opponent, RS Berkane.
Zamalek applied significant pressure on the visitors from the beginning of the game, with defensive midfielder Nabil Emad and Senegalese winger Ibrahima Ndiaye missing two early chances in the opening minutes.
The White Knights maintained control of the field and capitalized on a back pass from Ahmed 'Zizo' Sayed in the 23rd minute, allowing Ahmed Hamdi to score with a well-placed shot.
RS Berkane attempted to respond, but their attacks were not sufficient to pose a real threat to Zamalek, who opted to control the tempo and contain the visitors.
Hamdi sustained a knee injury near the end of the first half and was substituted by Youssef ‘Obama’ Ibrahim, who made his first appearance in around two months.
Obama missed a golden opportunity to double the lead just before halftime from close range.
Zamalek continued their strong start in the second half, coming close to scoring through Seif Jaziri's close-range header that went over the goal.
In the second half, Zamalek focused on their defensive efforts, allowing their opponent to control the midfield without creating significant threats.
Zamalek faced another injury in their midfield as Mohamed Shehata was replaced by Zeyad Kamal due to a muscle injury.
RS Berkane had a penalty claim in the 62nd minute, but the referee dismissed their appeals.
In the remaining minutes, RS Berkane made attempts to score, but their efforts lacked precision, easily handled by Zamalek's goalkeeper and defense.
In the dying moments of the match, Hamza El Moussaoui received a direct red card for a harsh tackle on Ahmed 'Zizo' Sayed.
The 12 minutes added in stoppage time did not bring any significant developments as Zamalek secured the title with their narrow victory.
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