Their arch-rivals Ahli are on the verge of clinching a second consecutive league title, needing just a single point from their remaining four matches to be crowned Egyptian champions.
Meanwhile, Pyramids FC has secured the second position, leaving Zamalek trailing by 21 points.
In light of this, Zamalek is striving to secure the third place, offering a modest consolation to their supporters after a season to forget.
Currently tied with fourth-placed Masry at 52 points, Zamalek is determined to edge ahead in the standings.
Coach Jose Gomez's lineup for Zamalek remains unpredictable, as he frequently makes alterations, providing young players with valuable playing time.
Zamalek have successfully avenged their defeats in the first round in recent matches, triumphing over Gouna 1-0 and Enppi 4-2 respectively.
Both Gouna and Enppi had bested Zamalek in the initial encounters, with scores of 3-2 and 2-1, respectively.
ZED FC delivered an upset to Zamalek in their inaugural appearance in the domestic league, claiming a 2-1 victory.
Consequently, the White Knights are eager to retaliate, mirroring their recent successes against Gouna and Enppi.
ZED FC currently holds the seventh spot in the league table with 47 points from 30 games.
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