The White Knights fielded a team primarily composed of youth players, supplemented by three senior players, including Mahmoud 'Shikaballa' Abdel-Razek.
Former Zamalek striker Omar El-Saed struck against his former club, giving Talae El-Geish the lead in the 25th minute.
Zamalek's Samason Akinyoola leveled the score in the 35th minute, but Talae El-Geish responded swiftly with Karim Tarek finding the net six minutes later.
In the 74th minute, a Zamalek midfielder handled the ball inside the box, resulting in a penalty for Talae El-Geish.
Mohamed Hamdi Zaki successfully converted the penalty, extending Talae El-Geish's lead to 3-1 as they concluded their league campaign in the tenth position with 42 points.
Despite this loss, Zamalek maintain their position in third place on the league table with 55 points, holding a three-point advantage over fourth-placed Masry.
Zamalek's season will draw to a close on Saturday when they face relegated side Baladeyet El-Mahala.
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