Mohamed was set sent clear by tino Kadewere to score his team's third goal just 11 minutes after being introduced in the 74th minute.
This marks his third consecutive game not starting under coach Antoine Kombouaré following uncertainties surrounding his futur over the summer.
The 26-year old international striker has been expecting offers, as reported by his coach Kombouaré.
French newspaper L'Équipe reported interest from Premier League side Leicester City, who were in advanced talks with Nantes about acquiring Mostafa Mohamed before the transfer deadline, claiming that the former Galatasaray frontman has become surplus to Nantes' needs.
Additionally, L'Équipe noted that the former Zamalek striker rejected a €15 million offer from an unnamed Saudi club.
Moreover, La Liga side Leganés has also shown interest, according to the French publication.
"I waited until the end of the transfer window to tell the players that, with the team we have, we should be capable of achieving much better than the previous season," Kombouaré said on Friday.
Initially joining Nantes on a one-season loan in the summer of 2022, Mohamed scored 11 goals and provided 5 assists in 51 games across all competitions, which made Nantes make his move permanent the following season.
In the 2023/2024 season, Mostafa Mohamed played 29 games for Nantes, scoring 8 goals and providing 2 assists
The Egyptian striker is among seven foreign-based players called up by coach Hossam Hassan for Egypt's upcoming 2025 Africa Cup of Nations qualifiers against Cape Verde and Botswana.
Mostafa Mohamed has been a key figure in the national team's attack, scoring 12 goals in 32 appearances.
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