The Whites secured a 1-0 away victory last week, giving themselves a comfortable advantage heading into the return fixture.
"Our primary goal was to win and we did it," Zamalek coach Jose Gomes said after the match.
The Portuguese tactician may deploy new signings like Polish winger Konrad Michalak, Senegalese striker Sidy Ndiaye, Palestinian forward Omar Faraj, and Moroccan left-back Mahmoud Bentayg, to get some playing time before the Super Cup showdown against Ahly.
"We are now a stronger team compared to last season, thanks to the time we've spent together and our preparations for the tournaments we're participating in," Gomes added.
Debutants Police FC are hoping to pull off a surprise in Cairo and advance to the group stage.
They qualified for this round after a hard-fought 1-0 aggregate win over Ethiopia Coffee SC.
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