IF Elfsborg's Sweden’s defender #08 Sebastian Holmen fights for the ball with Athletic Bilbao's Spanish defender #15 Inigo Lekue during the UEFA Europa League 1st round day 5 football match between Athletic Club Bilbao and IF Elfsborg at the San Mames stadium in Bilbao. AFP
Adama Boiro, Benat Prados and Gorka Guruzeta scored the goals as Bilbao climbed to second place, behind Lazio on goal difference.
The Roman club were held to a goalless draw by Ludogorets but remain unbeaten with 13 points from five games.
Victor Osimhen scored his seventh goal in as many matches for Galatasaray in all competitions as the Turkish giants remained third, two points behind the leading duo, after a 1-1 draw at AZ Alkmaar.
Lyon climbed into the top eight with a 4-1 thrashing of Qarabag in Baku, with Georgia striker Georges Mikautadze netting an excellent double.
Later Thursday, Ruben Amorim will take charge of Manchester United at Old Trafford for the first time against Bodo/Glimt, while Tottenham host crisis-hit Roma.
Chelsea remained top of the Conference League table with a hard-fought 2-0 win over Heidenheim, who lost their 100-percent record.
Enzo Maresca made 10 changes to the side which beat Leicester in the Premier League at the weekend.
But the Blues dominated the first half, with Heidenheim goalkeeper Kevin Mueller keeping them at bay with a string of fine saves.
Chelsea needed only six minutes after the restart to break the deadlock, though, as Christopher Nkunku took a brilliant touch to control Jadon Sancho's cross before firing into the top corner.
Nkunku, behind Nicolas Jackson in Maresca's Premier League pecking order, has scored five goals in four Conference League games this season.
The German side improved after falling behind, though, and almost equalised in the 69th minute when Chelsea goalkeeper Filip Jorgensen produced a wonderful double save to deny Paul Wanner and Leo Scienza.
The two-time European champions killed the game off with four minutes left as Sancho notched his second assist of the match, teeing up Mykhailo Mudryk to drive a shot into the roof of the net after playing a one-two with Kiernan Dewsbury-Hall.
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