The civil defence agency said a dawn airstrike on the home of the al-Ghoula family in Gaza City killed 11 people, seven of them children.
AFP images from the Gaza City area neighbourhood of Shujaiya showed residents combing through smoking rubble. Bodies, including those of small children, were lined up on the ground, shrouded in white sheets.
Meanwhile, medical sources told Al Jazeera that “66 people killed in Israeli raids on the Gaza Strip since dawn on Saturday, 41 of them in northern Gaza."
'Everything was shaking'
Civil defence spokesman Mahmud Bassal said the Ghoula home in Gaza City "was destroyed" by the dawn strike.
"It was a two-storey building and several people are still under the rubble," he said, adding Israeli drones had "also fired on ambulance staff."
Contacted by AFP, the Israeli army did not immediately comment on the strike.
"A huge explosion woke us up. Everything was shaking," said neighbour Ahmed Moussa.
"It was home to children, women. There wasn't anyone wanted or who posed a threat."
Elsewhere, the civil defence agency said an Israeli strike killed five security officers tasked with accompanying aid convoys as they drove through the southern city of Khan Younis.
Bassal accused Israel of having "deliberately targeted" them to "affect the humanitarian supply chain and increase the suffering" of the population.
United Nations rights experts said on Monday that the north Gaza "siege" appears to be part of an effort "to permanently displace the local population as a precursor to Gaza's annexation".
Rescuers said other Israeli strikes in the strip killed 10 more people.
AFP images showed Palestine Red Crescent paramedics in Gaza City moving the body of one of their colleagues, his green jacket laid over the blanket that covered his corpse.
The health ministry in Gaza said a total of 136 people had been killed over the previous 48 hours.
Israel has killed at least 45,717 people in Gaza, the majority of them women and children, according to figures from the Gaza Health Ministry, which the United Nations considers reliable.
Global outcry
Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO), has called for an immediate halt to Israeli military attacks on hospitals in Gaza.
In a press statement released on Saturday, Tedros emphasized the critical need for a ceasefire, particularly noting the ongoing disruption of health services in Gaza.
He stated: "Attacks on hospitals and health professionals must end. People in Gaza need access to health care."
Gaza health officials say one more key hospital on the northern edges of Gaza has been taken out of service by Israeli forces.
The Gaza Health Ministry said in a statement on Saturday that the Indonesian Hospital “no longer provides any services to patients or the wounded.”
On Friday, the occupation forces surrounded the health facility, which is home to many displaced Palestinians in the northern town of Beit Lahia and ordered the immediate evacuation of staff and patients.
According to the ministry, the North Gaza governorate has three public hospitals, Kamal Adwan, Beit Hanoun and the Indonesian Hospital, all of which are now out of service as the Israeli army forges ahead with a three-month-old campaign of ethnic cleansing in the north of the strip.
Beit Hanoun also received an evacuation order on Saturday.
The WHO Director also expressed concern over the fate of Dr Hussam Abu Safiya, the director of Kamal Adwan Hospital, who Israeli occupation soldiers abducted on 27 December during a raid on one of the last functioning medical facilities in the battered north of the Palestinian Strip.
"We have received no updates on the safety and well-being of its director Dr Hussam Abu Safiya since his detention on 27 December. We continue to urge Israel to release him."
Israel is facing mounting international pressure over its detention of the prominent paediatrician. Israel has made unfounded claims that he holds a position within Hamas, but these allegations have been presented without any evidence.
Rights organizations and UN officials have called for his immediate release or, at the very least, for Israel to disclose his whereabouts as concerns for his safety grow.
The UN Human Rights Office warned that Gaza’s health care system is on the brink of collapse, expressing "grave concern" over the fate of Abu Safiya, who it described as "yet another doctor to be harassed, kidnapped, and arbitrarily detained" by Israeli forces.
Amnesty International Secretary-General Agnes Callamard expressed alarm, warning that Abu Safiya is "at great risk of torture and ill-treatment" and called on Israel to reveal his location.
The Council on American-Islamic Relations (CAIR) has urged the Biden administration to pressure Israel for Abu Safiya's release.
Additionally, Physicians for Human Rights – Israel (PHRI) has filed a petition with Israel's Supreme Court, demanding transparency about his detention. PHRI also criticized Israel's broader pattern of withholding information about Palestinian detainees, highlighting Abu Safiya’s case as part of this troubling trend.
Ceasefire talks resume
Late on Friday, Hamas had said indirect negotiations with Israel were to resume in Qatar that same night for a truce and captive release deal. There has since been no update.
The Palestinian group said talks would "focus on ensuring the agreement leads to a complete cessation of hostilities (and) the withdrawal of occupation forces".
Mediators Qatar, Egypt and the United States have been engaged in months of effort that have failed to end nearly 15 months of genocidal Israeli war on the strip.
A key obstacle to a deal has been Israel's reluctance to agree to a lasting ceasefire.
More arms to Tel Aviv
As the clock ticks down to the handover of power in Washington, the outgoing administration of President Joe Biden notified Congress of an $8 billion arms sale to Israel, a source familiar with the plan said on Saturday.
"The department has informally notified Congress of an $8 billion proposed sale of F-15s and munitions to support Israel's long-term security by resupplying stocks of critical munitions and air defence capabilities," the official said.
The United States is Israel's largest military supplier, followed by Germany and Italy.
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