File Photo: England's Harry Kane shoots the ball during the World Cup round of 16 soccer match between England and Senegal, at the Al Bayt Stadium in Al Khor, Qatar. AFP
The two friendlies complete the schedule for the Three Lions in 2025, which is mainly focused on qualification for next year's World Cup.
Thomas Tuchel will take charge of England for the first time next month in World Cup qualifiers at home to Albania and Latvia.
The Euro 2024 finalists also face Serbia and Andorra in qualifying to reach the World Cup, which will be staged in the USA, Canada and Mexico.
The City Ground last hosted England's senior men's team for a competitive fixture in March 1909, a 2-0 Home Championship win against Wales.
Senegal will travel to Nottingham on June 10, while Wales make the short trip to London on October 9.
"The games against Senegal and Wales will present good challenges for us against two very different opponents," said Tuchel.
"Facing a strong African team in a passionate city with rich football heritage and then a derby match at the iconic Wembley; two big occasions that can only help us on the road to the World Cup.
"While I know Wembley is our home, I also understand the importance of taking the team around the country when we are able to and the opportunity to experience playing at a famous old English stadium such as the City Ground is one we can all look forward to."
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