Nasser Mansy canceled out, in the fifth minute of additional time of the first half, Mostafa Ziko's 25th-minute opener to concede a third straight draw in as many games.
Since his appointment on 14 February, Peseiro has yet to secure a victory, with Zamalek drawing 1-1 against Petrojet, Ahly, and ZED FC.
The result, Zamalek remain third in the table with 29 points, seven behind joint leaders Ahly and Pyramids FC. ZED FC sit 10th with 20 points from 16 matches.
Two set-pieces
Zamalek dominated possession against ZED FC who sat back on defence but were dangerous on the counter.
In the 25th minute Mostafa Ziko collected a poorly cleared corner to strike the opener from inside the area.
Zamalek pressed forward but struggled to capitalize on their chances. Mostafa Shalaby, Omar Gaber, and Zizo all missed key opportunities, with the latter striking the crossbar in the 35th minute.
Just before halftime, Nasser Mansy headed in a precise corner from Ahmed "Zizo" El Sayed.
Peseiro introduced Seifeddine Jaziri, Nasser Maher and young Tunisian winger Ahmed Jefali to bolster the attack, but ZED FC goalkeeper Ali Lotfi denied Zizo’s powerful effort late in the match.
Zamalek were reduced to 10 men in stoppage time after Mohamed Shehata received a second yellow card.
Zamalek will next face Enppi in their 17th league match on Tuesday.
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