The latest fatalities were reported in the southern city of Kosti, where the local water treatment plant shut down following an attack by the Rapid Support Forces (RSF). The assault cut access to clean drinking water, triggering a surge in infections.
The Ministry of Health blamed contaminated water for the outbreak and launched an emergency vaccination campaign.
The war between the paramilitary RSF and the Sudanese army, which began in April 2023, has caused widespread destruction to critical infrastructure, including water and power facilities, worsening the humanitarian crisis.
Nationwide, cholera has killed over 600 people and infected more than 21,000 since July last year, with a marked rise in infections reported in recent weeks, according to Ministry of Health figures cited by AP.
Health officials reported hundreds of new cases in Khartoum and surrounding regions as infrastructure continues to deteriorate.
The Sudan Doctors' Network said more than 500 patients were admitted to Khartoum's Al-Nou hospital alone, with nine deaths recorded on Thursday, 22 May.
"The surge in cases in such a short time is alarming and suggests that the outbreak is far worse than official numbers indicate," the network said in a statement.
Doctors Without Borders confirmed the spread of cholera to several states, including Senar and Gezira. In Senar, Health Minister Ibrahim al-Awad Ahmad reported 23 suspected cases and three deaths over a few days, according to CNN Arabic.
Meanwhile, CNN Arabic quoted Khartoum Health Minister Heitham Mohamed Ibrahim as saying that the outbreak is "a natural consequence of deteriorating environmental conditions" caused by the war.
He added that the destruction of water infrastructure and persistent power outages have left millions without access to clean drinking water. CNN Arabic reported that infection rates in Khartoum have reached 600 to 700 cases per week.
Over 60 percent of Sudan's water treatment facilities are out of service. In many areas, residents are forced to queue for hours at distribution points with no guarantee that the water is safe.
"We are seeing long queues at water distribution points, with no guarantee that the water is safe," one resident told Sky News Arabia.
Hospitals are struggling to cope. Sky News Arabia says over 70 percent of Sudan's health facilities are partially or fully non-operational. Many lack essential medical supplies, and some treat patients on the streets.
In Omdurman, near Khartoum, medical volunteers reported cases with symptoms that do not match typical cholera presentations. "Most are presenting with severe headaches and stomach pains, but without the usual diarrhea or vomiting associated with cholera," a local volunteer told Sky News Arabia.
Some cases are suspected to be linked to exposure from a weapons storage facility, and investigations are ongoing.
With the rainy season approaching, health experts warn that conditions could worsen rapidly. Aid organisations and medical workers are calling for urgent international assistance to help contain the outbreak and prevent further deaths.
"The situation is dire, and more deaths are expected in the coming days," a Ministry of Health spokesperson said.
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