People and rescuers inspect the damage at the site of a reported suicide attack at the Saint Elias church in Damascus' Dwelaa area on June 22, 2025. Syrian state media reported a suicide attack on a Damascus church. AFP
"This heinous and cowardly violence against Christians is an attack against all Syrians," said a statement from EU foreign policy spokesperson Anouar El Anouni on the attack, blamed by Syrian authorities on the Islamic State group.
"It is a grave reminder of the need to intensify efforts against the terrorist threat and to ensure the enduring defeat of Daesh and other terrorist organisations," El Anouni said, using an alternative name for IS.
A shooting and suicide bombing at a Damascus church during a packed service on Sunday killed at least 22 people, authorities said, blaming a member of the Islamic State group for the unprecedented attack.
The attack was the first of its kind in the Syrian capital since Islamist-led forces toppled longtime ruler Bashar al-Assad in December.
It was also the first inside a church in Syria since the country's civil war erupted in 2011, according to a monitor.
Security remains one of the most significant challenges for Syria's new authorities, with the international community repeatedly urging them to protect minorities.
AFP correspondents saw first responders transporting people from the Orthodox church as security forces cordoned off the area.
The church itself was strewn with wood from fittings and pews, with fallen icons and pools of blood on the floor.
"A suicide attacker affiliated with the Daesh (IS) terrorist group entered the Saint Elias church in the Dwelaa area... opened fire then blew himself up with an explosive belt," an interior ministry statement said.
State news agency SANA, citing the ministry of health, reported a death toll of 22, with 63 injured.
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