AFP journalists in the Lebanese capital said three densely populated neighbourhoods in the heart of Beirut were hit on Wednesday.
In Bashoura, a whole building collapsed into a mound of rubble after being struck.
"It was at 4:00 am, we were asleep," said Sara Saleh, a 29-year-old woman displaced from Beirut's southern suburbs, long a Hezbollah bastion but where hundreds of thousands of people live.
"We fled in our pyjamas," she told AFP, after she and her family fled a school they were sheltering in nearby.
Lebanon's official National News Agency (NNA) earlier said a strike had hit an apartment in the central Zuqaq al-Blat neighbourhood, a densely populated area close to the government's headquarters and several embassies.
Two other strikes targeted apartments in the central Basta district, another heavily populated area that Israel struck during a 2024 war with Hezbollah.
This photograph shows the destroyed Qasmiye Bridge built over the Litani River, following an Israeli airstrike, in Qasmiye. AFP
An AFP correspondent saw emergency workers at the scene in Basta where the walls of apartments on two adjacent floors appeared to have been blasted off.
Another strike hit Zuqaq al-Blat later in the morning, where an AFP journalist saw people clearing dust and glass from cars and the streets.
Hezbollah's Al Manar TV said Mohammad Sherri, the director of its political programmes, had been killed along with his wife in one of the strikes in Zuqaq al-Blat.
Lebanese Information Minister Paul Morcos said that targeting "media professionals constitutes a flagrant violation of international law."
Hezbollah condemned the Israeli assassination of Sherri, describing it as a "deliberate attack."
Lebanon's health ministry reported a preliminary toll for strikes on both areas of 12 dead and 41 wounded, adding that efforts were underway to identify those killed.
Israeli strikes also hit Beirut's southern suburbs, which Israel has pounded since the start of the war, and towns and villages across south Lebanon.
In south Lebanon, Israel shelled two bridges across the Litani River, which splits the south, the NNA reported.
AFP photos showed a bridge in an agricultural area north of the southern city of Tyre partially destroyed, with fires burning in the surrounding brush.
Israel also struck at least five gas stations belonging to the Al-Amana fuel company.
This came as Hezbollah announced it had repelled an attempt by "Israeli enemy soldiers to advance" in Khiyam, a town about six kilometres (four miles) from the border that has witnessed fierce clashes in recent days.
In the coastal city of Sidon, an Israeli strike hit a vehicle near the main seaside road, where many displaced people are staying and sleeping in their cars, according to an AFP correspondent.
The health ministry said two people were killed, including a civil defence rescuer.
In a statement on Wednesday, the UN peacekeeping force in Lebanon (UNIFIL) said: "last night's violent escalation marks a further worrying deterioration".
"Heavy exchanges of fire, intensified air and ground activity, and increased presence of Israeli forces inside Lebanese territory are deeply concerning developments," it added.
Meanwhile, Hezbollah condemned on Wednesday the Israeli killing of Iranian national security chief Ali Larijani, calling it "cowardly".
"We in Hezbollah, as we condemn this cowardly assassination and the ongoing criminal American-Israeli aggression, affirm that the assassination of leaders will neither break the will of the Islamic Republic nor undermine the determination of its leadership, its people, and its fighters," the group said.
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