The first leg will take place 17-19 March while the second leg is set to be played in Egypt between 1-3 April.
Tunisian side Africain have qualified after their 4-0 victory over Rwanda’s APR on Friday completed a 6-2 aggregate win, while Zamalek went through at the expense of Kenya’s Ulinzi Stars.
The White Knights will travel to Tunisia after ending their training camp in Syria, hosted by local club Hittien.
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