The Liverpool forward left the field injured on Thursday as Egypt played out a 2-2 draw.
The Egyptian FA have announced that Salah suffered a hamstring strain and will miss the Pharaos’ next two matches.
As a result, he is ruled out of their final group match against Cape Verde as well as the round of 16, if they qualify.
Egypt are currently second in group B after drawing their first two matches, with a win in the final fixture guaranteeing progression.
However, they will now have to do so without their star man, against a side that has already won the group.
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