Egypt’s Assistant Foreign Minister for African Affairs, Ambassador Sherif Issa marked the inauguration by landing at Djibouti–Ambouli International Airport in the first direct air flight from Cairo.

Djibouti's Minister of Islamic Affairs and Awqaf Moamen Hassan Berri and Minister of Trade and Tourism Mohamed Warsama Dirieh received the Egyptian diplomat upon his arrival.

Berri stated the launch of the new direct flight route between the two countries is evidence of the ongoing momentum in bilateral relations following President Abdel-Fattah El-Sisi's visit to Djibouti in May 2021, and the Djiboutian president's visit to Cairo in February.

From his side, Ambassador Sherif Issa said that the launch of the new direct flight route will help advance bilateral cooperation. He also pointed to recent cooperation projects between Egypt and Djibouti, including a project to establish a logistics zone at the Free Zone of Djibouti (DFZ), opening a new branch of Egypt's Banque Misr and building an Egyptian pediatric and gynecologic hospital.