A file photo of Al-Azhar headquarters in Cairo (Photo: Al-Ahram)
In a statement on Monday evening, Al-Azhar said the silence of the international community on Israeli violations in Hebron is unacceptable.
The international community has failed to play a serious role in affirming the inviolability of peoples and their sanctuaries, it added.
Israeli settlers tore and burnt copies of the Quran near the Ibrahimi Mosque, the Palestinian WAFA news agency reported on Monday, citing a local official in the old town.
The incident took place nearly a week after photos and videos were circulated over the past few days showing settlers dancing and singing inside the Ibrahimi Mosque, which Israeli authorities usually close to Palestinians during Jewish holidays.
Al-Azhar said "the scene demonstrates Zionism's barbarism, terrorism and hateful racism."
Al-Azhar also stressed that these crimes fuel the sentiments of violence and hatred and contradict international conventions, calling on Arabs and Muslims to unite in the face of violations of sanctities.
"The Noble Quran will remain a sublime scripture that guides humanity and steers it to the values of goodness," Al-Azhar added.
Hebron -- recognised by the UNESCO in 2017 as a world heritage site -- is the largest city in the occupied West Bank with a population of over 215,000 Palestinians.
The Ibrahimi Mosque, established in 1320 AD and believed to be built over the tombs of Prophet Abraham and his family, is revered by Muslims.
Israeli settlers are concentrated in the centre of the city; they regularly attack Palestinian residents and storm the mosque.